Acidosis, Lactic/chemically induced; Animals; Diabetes Mellitus, Type 2/metabolism; Glucose/metabolism*; Humans; Hypoglycemic Agents/pharmacokinetics; Hypoglycemic Agents/pharmacology*; Intestinal Absorption/drug effects*; Lactates/blood; Lactic Acid; Metformin/pharmacokinetics; Metformin/pharmacology*. Volume 11, Issue Supplement S1 September Pages S23–S Diabetes/Metabolism Research and Reviews. Previous article in issue: Effect of metformin on liver insulin metabolism and regional blood flow. Previous article in issue: Effect of metformin on liver insulin metabolism and regional blood flow. Next article in.
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To investigate the effect of metformin on intestinal glucose absorption, a perfusion study of the intestine was performed in the rat. Male Wistar albino rats (8 weeks old) were used in the present study. The glucose absorption by the perfused intestine ( ± μmol/30 min) was not changed significantly by the direct. To the Editor: The antihyperglycaemic effect of metformin is generally attributed to a decrease in hepatic glucose output, with some additional effects that increase peripheral glucose uptake and utilisation . The intestine also makes an important contribution to the glucose-lowering effect of metformin, but this is often.
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