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Nicardipine vs nifedipine

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Int J Clin Pharmacol Res. ;8(6) Nicardipine versus nifedipine: multicentre controlled trial in essential hypertension. Rumboldt Z(1), Stojanova D, Drinovec J, Marinković M, Nesović M, Srbinovski M, Bagatin J, Nikodijević B, Stalc A. Author information: (1)Clinical Pharmacology Unit, Clinical Centre, Split. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Nicardipine also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December.

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Nicardipine is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Nicardipine is called a calcium channel blocker. It works by relaxing blood vessels so blood can flow more easily. Nicardipine is also. tissue preparations, nicardipine was compared with dil- tiazem, nifedipine, and verapamil and found to have at least twice the specificity for vascular tissue versus papil- lary muscle than the other calcium blockers.' In a separate study, the relative specificity of nicardipine and nifedipine for vascular tissue was compared in.

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